By Alois Čihák PhD, Werner Reutter MD (auth.)
This quantity stories a sequence of alternative courses facing orotic acid. Orotic acid was once remoted from cow's milk seventy five years in the past via Biscaro and Belloni in Italy. Fifty years later back Italian scientists defined the growth-promoting task of orotic acid in nutrition B -deficient animals. 12 Orotic acid is the precursor of pyrimidine nucleotides that are serious about many biochemical reactions: UTP and CTP, as substrates for RNA polymerase, and UDP sugars, as substrates for carbohydrate containing macromolecules, e.g. glycogen, glycoproteins and glycolipids. The biosynthesis of those pyrimidines is easily regulated. Disturbance of the biosynthetic pathway or trapping of person pyrimidine nucleotides could lead to critical metabolic and structural adjustments of cells. Synthesis, biochemical facets and physiological function are reviewed in 9 chapters. within the final twenty years expanding curiosity in orotic acid got here from numerous reports exhibiting protecting or healing or helpful results of this compound in numerous forms of organ accidents: a number of varieties of hepatic insufficiency, myocardial infarction, encephalopathy, memorization professional cesses, pointed out in Chapters eight and nine. on the finish of this evaluate a Bibliography in an alphabetical order with 673 references can give additional perception during this topic.
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Diplock, A. T. and Green, J. Vitamin E and hepatotoxic agents. II. Lipid peroxidation and poisoning with orotic acid, ethanol and thioacetamide in rats. Br. J. , 23, 309-317 (1969) B45 Buskirk, J. J. and Kirsch, W. M. Loss of hepatoma ribosom54 OROTIC ACID a1 RNA during warfarin therapy. Biochem. Biophys. Res. 568 (1973) B46 Buyanovskaya, O. A. Effect of orotic acid on the formation of antibodies during changed reactivity of an organism. Nov. Biokhim. Fiziol. Vitam. A. (1973) 51707z) B47 Byrnes, K.
Arch. Biochem. -H. and Larson, B. L. Pyrimidine synthesis pathway enzymes and orotic acid in bovine mammary tissue. 1. , 54, 842-846 (1971) C25 Cheng, C. C. and Roth, B. Pyrimidines of biological and medicinal interest. II. Prog. Med. , 7, 285-341 (1970) C26 Chou, 1. Y. and Dickman, S. R. Effects of urecholine and atropine on canine pancreas slices. On incorporation of 57 OROTIC ACID adenine and orotic acid into acid-soluble metabolites and RNA. Arch. Biochem. , 135, 435-450 (1969) C27 C28 C29 C30 C31 C32 C33 C34 C35 Christopherson, R.
Fac. Med. Univ. Brun. Purkynianae, 49, 259 (1976) 464. Matsuda, I. and Shirahata, T. Tohoku J. Exp. , 90, 133 (1966) 465. , Hinkel, G. K. and Schwarze, R. Acta Paediatr. , 60, 1 (1971) 466. -W. and Hinkel, G. K. Acta Paediatr. , 60, 705 (1971) 43 OROTIC ACID 467. Gray, D. W. G. and Mowat, A. P. Arch. Dis. , 46, 123 (1971) 468. , Hinkel, G. , Koslowski, H. and Schwarze, R. Acta Paediatr. , 61, 703 (1972) 469. Hinkel, G. , Schwarze, R. -W. Acta Paediatr. Acad. Sci. , 13, 367 (1972) 470. Hinkel, G.
Orotic Acid by Alois Čihák PhD, Werner Reutter MD (auth.)