Get Biomarkers in Oncology: Prediction and Prognosis PDF

By Armin Gerger M.D., Melissa J. LaBonte Ph.D. (auth.), Heinz-Josef Lenz (eds.)

ISBN-10: 1441997547

ISBN-13: 9781441997548

ISBN-10: 1441997555

ISBN-13: 9781441997555

This built-in ebook covers the total spectrum of melanoma biomarkers in improvement and scientific use. Predictive and prognostic markers are explored within the context of colon melanoma, breast melanoma, lung melanoma, prostate melanoma, and GIST. overseas specialists supply perception into toxicity markers and surrogate markers. cognizance is usually given to biomarker assay improvement, validation, and methods.

A strong software for choosing judgements on remedy, picking drug regimens, tracking the efficacy of therapy, and appearing individualized surveillance, biomarkers signify the leading edge of melanoma examine and remedy. As those applied sciences develop into more and more on hand for medical use, this booklet could be a necessary source for oncologists and translational researchers.

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In one study 2 Prognostic Markers in Breast Cancer 29 of 1,046 women with breast cancer without metastases at time of diagnosis, elevated preoperative serum marker of cancer antigen 15-3 was correlated with worse prognosis [46]. In another study of 362 node negative patients, prognostic contribution of CA 15-3 was highly significant and its relationship with prognosis is continuous with the risk of relapse increasing progressively from approximately 10 U/ml [47]. However, the use of MUC I antigen in peripheral blood to make treatment decisions on early breast cancer is unclear.

46. Formica V, Palmirotta R, Del Monte G, et al. Predictive value of VEGF gene polymorphisms for metastatic colorectal cancer patients receiving first-line treatment including fluorouracil, irinotecan, and bevacizumab. Int J Colorectal Dis. 2011;26:143–51. 47. Jubb AM, Harris AL. Biomarkers to predict the clinical efficacy of bevacizumab in cancer. Lancet Oncol. 2010;11:1172–83. 48. Kweekel DM, Gelderblom H, Guchelaar HJ. Pharmacology of oxaliplatin and the use of pharmacogenomics to individualize therapy.

7. Eng C. The evolving role of monoclonal antibodies in colorectal cancer: early presumptions and impact on clinical trial development. Oncologist. 2010;15:73–84. 8. Wilson PM, Labonte MJ, Lenz HJ. Molecular markers in the treatment of metastatic colorectal cancer. Cancer J. 2010;16:262–72. 9. Tejpar S, Bertagnolli M, Bosman F, et al. Prognostic and predictive biomarkers in resected colon cancer: current status and future perspectives for integrating genomics into biomarker discovery. Oncologist.

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Biomarkers in Oncology: Prediction and Prognosis by Armin Gerger M.D., Melissa J. LaBonte Ph.D. (auth.), Heinz-Josef Lenz (eds.)

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