Atrial Hormones and Other Natriuretic Factors - download pdf or read online

By Adolfo J. De Bold (auth.), Patrick J. Mulrow, Robert Schrier (eds.)

ISBN-10: 0683061542

ISBN-13: 9780683061543

ISBN-10: 1461475295

ISBN-13: 9781461475293

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Extra info for Atrial Hormones and Other Natriuretic Factors

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Stored APir levels were found to be elevated about threefold over sham-operated controls in the left but not right ventricle (Fig. 1). In the same animals the levels of AP mRNA were also determined and found to be increased by a similar amount (Fig. 2). At the same time, left atrial APir content is depressed and circulating APir is somewhat increased. The effect on AP mRNA is at least somewhat specific. Although one of the effects of hypertrophy is an increase in the general level of protein synthesis, the relative levels of mRNA for creatine kinase (CK) are unchanged during treatment.

62: 9-22, 1984. 36. , R. S. SIDER, E. A. 0STAFIN, AND R. J. GREKIN. Plasma levels of immunoreactive atrial natriuretic factor in healthy subjects and in patients with edema. J. Clin. Invest. 76: 1684-1687, 1985. 37. , R. F. KREBS, AND A. T. VERESS. Release of atrial natriuretic factor from incubated rat heart atria. IRCS Med. Sci. Libr. Compend. 12: 783-784, 1984. 38. , AND A. T. VERESS. Cellular mechanism of release of atrial natriuretic factor. Biochem. Biophys. Res. Commun. 124: 443-449, 1984.

The ANF in several hypothalmic regions in the rat is markedly reduced by dehydration (56). In addition to the atria, ventricle, and brain, immunoreactive ANF has been reported in the retina (63), chorion (A. Poisner and T. Imada, unpublished observations), and testis. Immunohistochemical studies also revealed its presence in adrenomedullary chromaffin cells, anterior pituitary cells, and intercalated cells of the renal collecting duct of rats (35). MOLECULAR PROPERTIES OF ANF Although ANFs of various chain lengths have been isolated from the atria of the heart, later studies conducted with specific care to minimize the degradation of ANF during extraction indicate that immunoreactive ANF in rat atrium is predominantly in high-molecular-weight form (12, 20, 39, 64, 69, 47 TISSUE DISTRIBUTION OF ANF 73).

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Atrial Hormones and Other Natriuretic Factors by Adolfo J. De Bold (auth.), Patrick J. Mulrow, Robert Schrier (eds.)


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