Read e-book online Androgens in Health and Disease PDF

By Stephen J. Winters MD, Barbara J. Clark PhD (auth.), Carrie J. Bagatell MD, William J. Bremner MD, PhD (eds.)

ISBN-10: 1588290298

ISBN-13: 9781588290298

ISBN-10: 1592593887

ISBN-13: 9781592593880

ISBN-10: 1617373141

ISBN-13: 9781617373145

In fresh years, clinical researchers have validated that androgens, either evidently happening and artificial, effect a myriad of physiological capabilities and will even be used therapeutically in a large choice of medical settings. In Androgens in well-being and illness, an authoritative panel of researchers and clinicians evaluate our most recent knowing of andrology in either simple technology and medical medication. issues variety from explaining the biology of androgens-from numerous diverse perspectives-to illuminating their position within the improvement and modulation of physiologic platforms. The authors exhibit how testosterone could be a precious adjunct to the remedy of a number of disorder states, rather these during which catabolism and lack of muscle groups happen. different chapters give some thought to very important themes similar to androgen use in athletes, the possibility of androgens to enhance actual functionality and caliber of existence in older males, and androgens as capability male contraceptives. Of particular curiosity is a presentation of contemporary advances in knowing the physiological and medical results of androgen extra and androgen deficiency in ladies.
Authoritative and wide-ranging, Androgens in healthiness and illness deals either researchers and working towards clinicians a entire survey of ways, why, and the place androgens exert their results, in addition to their healing roles in a vast variety of diseases.

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Repression of cAMP-induced expression of the mouse P450 17 alpha-hydroxylase/CI7-20 lyase gene (Cypl7) by androgens. Mol Endocrinol 1997;11:87-96. 67. Abney TO. The potential roles of estrogens in regulating Leydig cell development and function: a review. Steroids 1999;64:610-617. 68. Sankar BR, Maran RR, Sivakumar R, et al. Chronic administration of corticosterone impairs LH signal transduction and steroidogenesis in rat Leydig cells. J Steroid Biochem Mol Biol 2000;72: 155-162. 69. Goldsmith PC, Thind KK, Song T, et al.

Sankar BR, Maran RR, Sivakumar R, et al. Chronic administration of corticosterone impairs LH signal transduction and steroidogenesis in rat Leydig cells. J Steroid Biochem Mol Biol 2000;72: 155-162. 69. Goldsmith PC, Thind KK, Song T, et al. Location of the neuroendocrine gonadotropin-releasing hormone neurons in the monkey hypothalamus by retrograde tracing and immunostaining. J Neuroendocrinol 1990;2: 157-168. 70. Caraty A, Locatelli A. Effect oftime after castration on secretion ofLHRH and LH in the ram.

The critical features ofprotein-DNA binding that differentially determine the specificity of AR, GR, and PR binding to DNA regulatory sequences, and hence their discriminatory function in steroid-specific gene regulation, are now under scrutiny. Recent experiments have identified genes that are specifically responsive to androgens and analysis of the AR -binding sites in their promoters has revealed SRE motifs that resemble direct nuc1eotide repeat sequences rather than palindromic, inverted nuc1eotide repeat sequences (38) (see Table 1).

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Androgens in Health and Disease by Stephen J. Winters MD, Barbara J. Clark PhD (auth.), Carrie J. Bagatell MD, William J. Bremner MD, PhD (eds.)


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