Professor Dr. Frank G. Holz, Professor Dr. Daniel's Age-related macular degeneration PDF

By Professor Dr. Frank G. Holz, Professor Dr. Daniel Pauleikhoff, MD Richard F. Spaide, Professor Alan C. Bird (auth.)

ISBN-10: 3662051990

ISBN-13: 9783662051993

ISBN-10: 3662052016

ISBN-13: 9783662052013

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5urv Ophthalmol 24 [5uppIJ:335610 Liu IY, White L, LaCroix AZ (1989) The association of age-related macular degeneration and lens opacities in the aged. (2000) Allelic variation in theVMD2 gene in best disease and age-related macular degeneration. Invest Ophthalmol Vis Sci 41 :1291-1296 Macular Photocoagulation Study Group (1993) Five-year follow-up of fellow eyes of patients with age-related macular degeneration and unilateral extrafoveal choroidal neovascularization. Arch OphthalmoI115:741-747 Maltzman BA, Mulvihill MN, Greenbaum A (1979) Senile macular degeneration and risk factors: a case-control study.

Arch OphthalmoI113:728-735 Schaft van der TL et al. (1994) Increased prevalence of disciform macular degeneration after cataract extraction with implantation of an intraocular lens. Br J Ophthalmol 78:441-445 Schaumberg DA et al. (2001) Body mass index and the incidence of visually significant age-related maculopathy in men. Arch OphthalmoI119:1259-1265 Schectman G, Byrd JC, Gruchow HW (1989) The influence of smoking on vitamin C status in adults. Am J Public Health 79:158-162 Schmidt S et al. (2000) Association of the apolipoprotein E gene with age-related macular degeneration: possible References effect modification by family history, age, and gender.

Such molecules cannot be "recognized" by lysosomal RPE enzymes and are, therefore, undegradable. This would lead to accumulation of material in the lysosomal compartment of RPE cells and may thus impair various pigment epithelial functions. Other findings that strengthen the hypothesis of oxidative mechanisms in the pathogenesis of AMD include the fact that race (caucasians) and light iris color are known risk factors. Furthermore, there is correlation between RPE lipofuscin accumulation and distribution of drusen, and studies have shown a reduction in antioxidative enzyme activity in the RPE with age as well as an age-related reduction in antioxidative yellow macular pigment that also serves as a UV filter.

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Age-related macular degeneration by Professor Dr. Frank G. Holz, Professor Dr. Daniel Pauleikhoff, MD Richard F. Spaide, Professor Alan C. Bird (auth.)


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