By Gerd Plewig Prof. Dr., Albert M. Kligman M.D., Ph.D. (auth.)
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Sweating makes the skin look greasier than it actually is, causing difficulties in assessing the actual degree of oiliness. Effect of Temperature. Changes in skin temperature influence the sebum excretion rate by about 10% per degree Celsius. However, as these changes occur within 90 min, the effect is mainly on preformed sebum in the follicular reservoir. Sebum secretion seems to follow a circadian rhythm, being highest during the first hours of sleep, and to increase in the summer months. This might be due to higher skin temperature making sebum less viscous.
The term anti androgens term usage rule out clinical applications. is applied to drugs which act either by The drug is ineffective topically. Other blocking the enzyme 5oc-reductase that anticholesterol drugs such as clofibrate converts testosterone to DHT or by com- and nicotinates have not been able to repeting with androgens for receptor-bind- duce sebum production. Wheatley VR (1986) In: Jarrett A (ed) The physiology and pathophysiology of the skin, vol 9. Academic Press, London, pp 2724-2726; 2788-2792 44 Antibiotics.
For example, phospholipids which contain large amounts of unsaturated fatand sugars. Cholesterol should be mentioned partic- ty acids, including linoleic acid and ularly because it cannot be synthesized arachidonic acid, predominate in lower by these insects and therefore must be cell layers. They are reduced in granular taken up with their diet. The fact that cells and are present in only very small cholesterol is nevertheless always invari- amounts in the stratum corneum. In ex- 26 periments with rodents it could be shown that linoleic acid, an essential fatty acid, is of great importance for epidermal barrier function.
ACNE and ROSACEA by Gerd Plewig Prof. Dr., Albert M. Kligman M.D., Ph.D. (auth.)